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1994-09-24
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Document 0700
DOCN M9490700
TI CD4 lymphocyte numbers after splenectomy in patients infected with the
human immunodeficiency virus.
DT 9411
AU Fairley CK; Spelman D; Street A; Jennens ID; Spicer WJ; Crowe S;
Department of Social and Preventive Medicine, Alfred Hospital,; Prahran,
Victoria, Australia.
SO Int J STD AIDS. 1994 May-Jun;5(3):177-81. Unique Identifier : AIDSLINE
MED/94339219
AB Splenectomy has been reported to alter inconsistently the CD4 lymphocyte
numbers in patients infected with the human immunodeficiency virus
(HIV). To further assess the effect of splenectomy we have
retrospectively examined the charts of 10 patients who were infected
with HIV and who had undergone splenectomy. There was a significant
increase in the mean CD4 numbers following splenectomy (mean increase of
326/microliters, or 2.1-fold, P = 0.0009), the total lymphocyte numbers
(mean increase of 1.55/ml, or 2.2-fold, P = 0.001) and in the CD8
lymphocyte count (mean increase of 968/microliters, or 2.3-fold, P =
0.014). No significant difference was observed in the percentage CD4
lymphocytes (P = 0.95) or in the CD4:CD8 lymphocyte ratio (P = 0.76). In
two patients, symptoms suggestive of impaired immune function developed
post-splenectomy, at a time when their CD4 lymphocyte numbers were
markedly higher than their pre-splenectomy values. One developed oral
candidiasis (CD4 960/microliters, percentage CD4 32%), and in one
patient a 7 kg weight loss was associated with recurrent mouth ulcers
(CD4 680/microliters, percentage CD4 7%). We conclude that the total CD4
count increases significantly after splenectomy while the percentage CD4
lymphocyte count and CD4:CD8 lymphocyte ratio do not. Our data suggest
that the CD4 lymphocyte count overestimates the immune function in these
patients, although our findings are not conclusive.
DE CD4-CD8 Ratio Human HIV Infections/BLOOD/*IMMUNOLOGY/SURGERY
Leukocyte Count Retrospective Studies *Splenectomy Support, Non-U.S.
Gov't *T4 Lymphocytes JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).